Building Medical Digital Twins with Pulse: Open Source Simulation Tools for Developers and Researchers
Webinar
×
NervousModel.h
1 /* Distributed under the Apache License, Version 2.0.
2  See accompanying NOTICE file for details.*/
3 
4 #pragma once
5 
6 #include "engine/common/system/Model.h"
7 #include "engine/common/system/Systems.h"
8 
9 class SEFluidCircuitNode;
10 class SEFluidCircuitPath;
11 class SEFluidCircuit;
12 
13 namespace pulse
14 {
15  class PBPhysiology;
16  class EngineTest;
21  class PULSE_DECL NervousModel : public NervousSystem, public Model
22  {
23  friend PBPhysiology;//friend the serialization class
24  friend EngineTest;
25  public:
26  NervousModel(Data& data);
27  virtual ~NervousModel();
28 
29  void Clear() override;
30 
31  // Set members to a stable homeostatic state
32  void Initialize() override;
33  // Set pointers and other member variables common to both homeostatic initialization and loading a state
34  void SetUp() override;
35 
36  void AtSteadyState() override;
37  void PreProcess() override;
38  void Process(bool solve_and_transport = true) override;
39  void PostProcess(bool solve_and_transport = true) override;
40 
41 
42  virtual void SetBaroreceptorFeedback(eSwitch s) override;
43  virtual void SetChemoreceptorFeedback(eSwitch s) override;
44 
45  protected:
46  void ComputeExposedModelParameters() override;
47 
48  void BaroreceptorFeedback();
49  void InitializeBaroreceptors();
50  void CheckBrainStatus();
51  void ChemoreceptorFeedback();
52  void SetPupilEffects();
53  void CerebralSpinalFluidUpdates();
54  void SetBaselines();
55 
56 
57  // Serializable member variables (Set in Initialize and in schema)
58  bool m_BaroreceptorFeedbackStatus;
59  bool m_BaroreceptorSaturationStatus;
60  double m_ArterialOxygenBaseline_mmHg;
61  double m_ArterialCarbonDioxideBaseline_mmHg;
62  double m_BaroreceptorActiveTime_s;
63  double m_BaroreceptorEffectivenessParameter;
64  double m_BaroreceptorSaturationTime_s;
65  double m_LastMeanArterialPressure_mmHg;
66  double m_PreviousBloodVolume_mL;
67  // Arrhythmia Support
68  eHeartRhythm m_PreviousHeartRhythm;
69  //double m_BaroreceptorPauseTimer;
70  //bool m_BaroreceptorPauseTimerStatus;
71 
72  //SERIALIZE THESE AARON - should be system values
73  double m_CSFAbsorptionRate_mLPermin;
74  double m_CSFProductionRate_mlPermin;
75 
76  // Stateless member variable (Set in SetUp())
77  // Configuration fractions representing the amount by which each quantity can change due to feedback;
78  double m_NormalizedGammaHeartRate;
79  double m_NormalizedGammaElastance;
80  double m_NormalizedGammaCompliance;
81  double m_NormalizedGammaResistance;
82  double m_NormalizedAlphaHeartRate;
83  double m_NormalizedAlphaElastance;
84  double m_NormalizedAlphaCompliance;
85  double m_NormalizedAlphaResistance;
86  double m_NormalizedBetaHeartRate;
87 
88  SEFluidCircuitNode* m_IntracranialSpace;
89  SEFluidCircuitPath* m_CSFProductAbsorptionPath;
90  SEFluidCircuitPath* m_BrainVasculatureCompliancePath;
91  SEFluidCircuitPath* m_BrainVasculatureResistancePath;
92  };
93 END_NAMESPACE
PBPhysiology
Definition: PBPhysiology.h:24
SEFluidCircuit
Definition: SEFluidCircuit.h:12
SEFluidCircuitNode
Definition: SEFluidCircuitNode.h:10
SEFluidCircuitPath
Definition: SEFluidCircuitPath.h:9
pulse
Definition: Logger.h:14

Distributed under the Apache License, Version 2.0.

See accompanying NOTICE file for details.