Hemorrhage-Class1Femoral

HemorrhageClass1Femoral

Description

15% blood loss (class 1 hemorrhage) from the femoral artery.

Segment Validation

Segment 1

Initiate a 90 ml/min hemorrhage from the right leg. Run for 550s.

Table 1. Data request validation results for Segment 1.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Baseline (72.0) [157]	87.7		21.68%	Increase
MeanArterialPressure(mmHg)	EqualTo Baseline (95.3) [157]	94.2	-1.09%		No Change
BloodVolume(mL)	EqualTo Baseline - 825 (4.66e+03)	4.69e+03	0.50%		Calculated
CardiacOutput(mL/min)	LessThan Baseline (5.78e+03) [157]	5.07e+03		-12.30%	Decrease
HeartStrokeVolume(mL)	LessThan Baseline (80.2) [157]	57.8		-27.92%	Decrease
HemoglobinContent(g)	EqualTo 700	698	-0.29%		Calculated
RespirationRate(1/min)	EqualTo Baseline (11.9) [157]	12.1	1.61%		No Change

Figure 1. Vitals monitor for Segment 1.

Table 2. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	76.7
HeartRate(1/min)	87.7
HeartStrokeVolume(mL)	57.8
HeartEjectionFraction	0.490
BloodVolume(L)	4.69
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	94.2
SystolicArterialPressure(mmHg)	109
DiastolicArterialPressure(mmHg)	78.1
CardiacOutput(L/min)	5.07
HemoglobinContent(g)	698
CentralVenousPressure(mmHg)	3.59
PulmonaryCapillariesWedgePressure(mmHg)	5.23
TidalVolume(mL)	517
RespirationRate(1/min)	12.1
OxygenSaturation	0.978
CarbonDioxideSaturation	0.0264
EndTidalCarbonDioxideFraction	0.0490
EndTidalCarbonDioxidePressure(mmHg)	37.2
TotalAlveolarVentilation(L/min)	4.43
TranspulmonaryPressure(cmH2O)	4.92
CoreTemperature(degC)	37.1
SkinTemperature(degC)	31.1
RespiratoryExchangeRatio	0.798
OxygenConsumptionRate(mL/min)	274
CarbonDioxideProductionRate(mL/min)	219
GlomerularFiltrationRate(mL/min)	95.2
RenalBloodFlow(L/min)	0.919
UrineProductionRate(mL/min)	0.787
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0446
RightAfferentArterioleResistance(mmHg_min/mL)	0.0446
SystemicVascularResistance(mmHg_s/mL)	1.07
Aorta-Oxygen-PartialPressure(mmHg)	95.8
Aorta-CarbonDioxide-PartialPressure(mmHg)	38.3
VenaCava-Oxygen-PartialPressure(mmHg)	36.0
VenaCava-CarbonDioxide-PartialPressure(mmHg)	45.0
RightTubules-Sodium-Concentration(g/L)	4.10
LeftTubules-Sodium-Concentration(g/L)	4.10
Oxygen-AlveolarTransfer(mL/min)	262
CarbonDioxide-AlveolarTransfer(mL/min)	-222
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	37.4
BrainVasculature-Oxygen-PartialPressure(mmHg)	37.3
MyocardiumVasculature-Inflow(mL/min)	189
BrainVasculature-Inflow(mL/min)	563
VenaCava-Inflow(mL/min)	4.97e+03
RightHeart-Inflow(mL/min)	2.48e-12
TotalHemorrhageRate(mL/s)	1.50
TotalHemorrhagedVolume(mL)	825
BaroreceptorHeartRateScale	1.23
BaroreceptorHeartElastanceScale	1.01
BaroreceptorResistanceScale	1.14
BaroreceptorComplianceScale	0.938
ChemoreceptorHeartRateScale	0.00832
ChemoreceptorHeartElastanceScale	1.00

Segment 2

Stop the hemorrhage. Run for 500s.

Table 3. Data request validation results for Segment 2.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	EqualTo Segment1 (87.7)	87.5	-0.16%		No Change
MeanArterialPressure(mmHg)	EqualTo Segment1 (94.2)	94.4	0.18%		No Change
BloodVolume(mL)	EqualTo Segment1 (4.69e+03)	4.71e+03	0.45%		No Change
CardiacOutput(mL/min)	EqualTo Segment1 (5.07e+03)	5.07e+03	-0.02%		No Change
HeartStrokeVolume(mL)	EqualTo Segment1 (57.8)	57.9	0.14%		No Change
HemoglobinContent(g)	EqualTo Segment1 (698)	698	0.00%		No Change
RespirationRate(1/min)	EqualTo Segment1 (12.1)	12.4	2.48%		No Change

Figure 2. Vitals monitor for Segment 2.

Table 4. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	76.7
HeartRate(1/min)	87.7
HeartStrokeVolume(mL)	57.8
HeartEjectionFraction	0.490
BloodVolume(L)	4.69
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	94.2
SystolicArterialPressure(mmHg)	109
DiastolicArterialPressure(mmHg)	78.1
CardiacOutput(L/min)	5.07
HemoglobinContent(g)	698
CentralVenousPressure(mmHg)	3.59
PulmonaryCapillariesWedgePressure(mmHg)	5.23
TidalVolume(mL)	517
RespirationRate(1/min)	12.1
OxygenSaturation	0.978
CarbonDioxideSaturation	0.0264
EndTidalCarbonDioxideFraction	0.0490
EndTidalCarbonDioxidePressure(mmHg)	37.2
TotalAlveolarVentilation(L/min)	4.43
TranspulmonaryPressure(cmH2O)	4.92
CoreTemperature(degC)	37.1
SkinTemperature(degC)	31.1
RespiratoryExchangeRatio	0.798
OxygenConsumptionRate(mL/min)	274
CarbonDioxideProductionRate(mL/min)	219
GlomerularFiltrationRate(mL/min)	95.2
RenalBloodFlow(L/min)	0.919
UrineProductionRate(mL/min)	0.787
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0446
RightAfferentArterioleResistance(mmHg_min/mL)	0.0446
SystemicVascularResistance(mmHg_s/mL)	1.07
Aorta-Oxygen-PartialPressure(mmHg)	95.8
Aorta-CarbonDioxide-PartialPressure(mmHg)	38.3
VenaCava-Oxygen-PartialPressure(mmHg)	36.0
VenaCava-CarbonDioxide-PartialPressure(mmHg)	45.0
RightTubules-Sodium-Concentration(g/L)	4.10
LeftTubules-Sodium-Concentration(g/L)	4.10
Oxygen-AlveolarTransfer(mL/min)	262
CarbonDioxide-AlveolarTransfer(mL/min)	-222
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	37.4
BrainVasculature-Oxygen-PartialPressure(mmHg)	37.3
MyocardiumVasculature-Inflow(mL/min)	189
BrainVasculature-Inflow(mL/min)	563
VenaCava-Inflow(mL/min)	4.97e+03
RightHeart-Inflow(mL/min)	2.48e-12
TotalHemorrhageRate(mL/s)	1.50
TotalHemorrhagedVolume(mL)	825
BaroreceptorHeartRateScale	1.23
BaroreceptorHeartElastanceScale	1.01
BaroreceptorResistanceScale	1.14
BaroreceptorComplianceScale	0.938
ChemoreceptorHeartRateScale	0.00832
ChemoreceptorHeartElastanceScale	1.00

Scenario Output Plots

Figure 3. Select outputs from the scenario.