HemorrhageClass1Femoral

Description

15% blood loss (class 1 hemorrhage) from the femoral artery.

Segment Validation

Segment 1

Initiate a 90 ml/min hemorrhage from the right leg. Run for 550s.

Table 1. Data request validation results for Segment 1.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Baseline (72.0) [152]	93.3		29.6%	Increase
MeanArterialPressure(mmHg)	EqualTo Baseline (95.3) [152]	94.0	1.42%		No Change
BloodVolume(mL)	EqualTo 4675	4.69e+03	0.346%		Calculated
CardiacOutput(mL/min)	EqualTo Baseline (5.79e+03) [152]	4.87e+03	17.3%		No Change
HeartStrokeVolume(mL)	LessThan Baseline (80.4) [152]	52.1		-35.1%	Decrease
HemoglobinContent(g)	EqualTo 700	698	0.259%		Calculated
RespirationRate(1/min)	EqualTo Baseline (12.0) [152]	12.4	3.25%		No Change

Figure 1. Vitals monitor for Segment 1.

Table 2. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	76.6
HeartRate(1/min)	93.3
HeartStrokeVolume(mL)	52.1
HeartEjectionFraction	0.466
BloodVolume(L)	4.69
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	94.0
SystolicArterialPressure(mmHg)	107
DiastolicArterialPressure(mmHg)	79.4
CardiacOutput(L/min)	4.87
HemoglobinContent(g)	698
CentralVenousPressure(mmHg)	3.70
PulmonaryCapillariesWedgePressure(mmHg)	4.92
TidalVolume(mL)	556
RespirationRate(1/min)	12.4
OxygenSaturation	0.970
CarbonDioxideSaturation	0.0285
EndTidalCarbonDioxideFraction	0.0487
EndTidalCarbonDioxidePressure(mmHg)	37.0
TotalAlveolarVentilation(L/min)	6.89
TranspulmonaryPressure(cmH2O)	7.15
CoreTemperature(degC)	37.1
SkinTemperature(degC)	32.7
RespiratoryExchangeRatio	0.807
OxygenConsumptionRate(mL/min)	283
CarbonDioxideProductionRate(mL/min)	229
GlomerularFiltrationRate(mL/min)	92.4
RenalBloodFlow(L/min)	0.821
UrineProductionRate(mL/min)	0.412
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0473
RightAfferentArterioleResistance(mmHg_min/mL)	0.0473
SystemicVascularResistance(mmHg_s/mL)	1.11
Aorta-Oxygen-PartialPressure(mmHg)	85.6
Aorta-CarbonDioxide-PartialPressure(mmHg)	40.5
VenaCava-Oxygen-PartialPressure(mmHg)	34.0
VenaCava-CarbonDioxide-PartialPressure(mmHg)	45.1
RightTubules-Sodium-Concentration(g/L)	4.65
LeftTubules-Sodium-Concentration(g/L)	4.65
Oxygen-AlveolarTransfer(mL/min)	248
CarbonDioxide-AlveolarTransfer(mL/min)	-181
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	34.8
BrainVasculature-Oxygen-PartialPressure(mmHg)	35.3
MyocardiumVasculature-InFlow(mL/min)	169
BrainVasculature-InFlow(mL/min)	514
VenaCava-InFlow(mL/min)	4.78e+03
RightHeart-InFlow(mL/min)	9.10e+03
TotalHemorrhageRate(mL/s)	1.50
TotalHemorrhagedVolume(mL)	825
BaroreceptorHeartRateScale	1.31
BaroreceptorHeartElastanceScale	1.02
BaroreceptorResistanceScale	1.18
BaroreceptorComplianceScale	0.915
ChemoreceptorHeartRateScale	0.164
ChemoreceptorHeartElastanceScale	1.00

Segment 2

Stop the hemorrhage. Run for 500s.

Table 3. Data request validation results for Segment 2.

Property Name	Validation	Engine Value	Percent Error	Notes
HeartRate(1/min)	EqualTo Segment1 (93.3)	92.4	1.01%	No Change
MeanArterialPressure(mmHg)	EqualTo Segment1 (94.0)	94.4	0.423%	No Change
BloodVolume(mL)	EqualTo Segment1 (4.69e+03)	4.72e+03	0.636%	No Change
CardiacOutput(mL/min)	EqualTo Segment1 (4.87e+03)	4.83e+03	0.761%	No Change
HeartStrokeVolume(mL)	EqualTo Segment1 (52.1)	52.3	0.250%	No Change
HemoglobinContent(g)	EqualTo Segment1 (698)	698	0.000206%	No Change
RespirationRate(1/min)	EqualTo Segment1 (12.4)	12.7	2.51%	No Change

Figure 2. Vitals monitor for Segment 2.

Table 4. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	76.6
HeartRate(1/min)	93.3
HeartStrokeVolume(mL)	52.1
HeartEjectionFraction	0.466
BloodVolume(L)	4.69
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	94.0
SystolicArterialPressure(mmHg)	107
DiastolicArterialPressure(mmHg)	79.4
CardiacOutput(L/min)	4.87
HemoglobinContent(g)	698
CentralVenousPressure(mmHg)	3.70
PulmonaryCapillariesWedgePressure(mmHg)	4.92
TidalVolume(mL)	556
RespirationRate(1/min)	12.4
OxygenSaturation	0.970
CarbonDioxideSaturation	0.0285
EndTidalCarbonDioxideFraction	0.0487
EndTidalCarbonDioxidePressure(mmHg)	37.0
TotalAlveolarVentilation(L/min)	6.89
TranspulmonaryPressure(cmH2O)	7.15
CoreTemperature(degC)	37.1
SkinTemperature(degC)	32.7
RespiratoryExchangeRatio	0.807
OxygenConsumptionRate(mL/min)	283
CarbonDioxideProductionRate(mL/min)	229
GlomerularFiltrationRate(mL/min)	92.4
RenalBloodFlow(L/min)	0.821
UrineProductionRate(mL/min)	0.412
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0473
RightAfferentArterioleResistance(mmHg_min/mL)	0.0473
SystemicVascularResistance(mmHg_s/mL)	1.11
Aorta-Oxygen-PartialPressure(mmHg)	85.6
Aorta-CarbonDioxide-PartialPressure(mmHg)	40.5
VenaCava-Oxygen-PartialPressure(mmHg)	34.0
VenaCava-CarbonDioxide-PartialPressure(mmHg)	45.1
RightTubules-Sodium-Concentration(g/L)	4.65
LeftTubules-Sodium-Concentration(g/L)	4.65
Oxygen-AlveolarTransfer(mL/min)	248
CarbonDioxide-AlveolarTransfer(mL/min)	-181
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	34.8
BrainVasculature-Oxygen-PartialPressure(mmHg)	35.3
MyocardiumVasculature-InFlow(mL/min)	169
BrainVasculature-InFlow(mL/min)	514
VenaCava-InFlow(mL/min)	4.78e+03
RightHeart-InFlow(mL/min)	9.10e+03
TotalHemorrhageRate(mL/s)	1.50
TotalHemorrhagedVolume(mL)	825
BaroreceptorHeartRateScale	1.31
BaroreceptorHeartElastanceScale	1.02
BaroreceptorResistanceScale	1.18
BaroreceptorComplianceScale	0.915
ChemoreceptorHeartRateScale	0.164
ChemoreceptorHeartElastanceScale	1.00

Scenario Output Plots

Figure 3. Select outputs from the scenario.