Hemorrhage-Class2Brachial

HemorrhageClass2Brachial

Description

25% blood loss (class 2 hemorrhage) from the brachial artery.

Segment Validation

Segment 1

Initiate a 60 ml/min hemorrhage from the right arm. Run for 1375s.

Table 1. Data request validation results for Segment 1.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Baseline (72.0) [157]	106		46.49%	Increase
MeanArterialPressure(mmHg)	LessThan Baseline (95.3) [157]	82.9		-12.96%	65-90%
BloodVolume(mL)	EqualTo Baseline - 1375 (4.11e+03)	4.15e+03	1.02%		Calculated
CardiacOutput(mL/min)	LessThan Baseline (5.78e+03) [157]	4.45e+03		-22.97%	50-90%
HeartStrokeVolume(mL)	LessThan Baseline (80.2) [157]	42.2		-47.41%	Decrease
HemoglobinContent(g)	EqualTo 620	616	-0.58%		Calculated
RespirationRate(1/min)	EqualTo Baseline (11.9) [157]	12.9	8.15%		No Change

Figure 1. Vitals monitor for Segment 1.

Table 2. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	76.3
HeartRate(1/min)	106
HeartStrokeVolume(mL)	42.2
HeartEjectionFraction	0.403
BloodVolume(L)	4.15
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	82.9
SystolicArterialPressure(mmHg)	94.1
DiastolicArterialPressure(mmHg)	71.3
CardiacOutput(L/min)	4.45
HemoglobinContent(g)	616
CentralVenousPressure(mmHg)	3.17
PulmonaryCapillariesWedgePressure(mmHg)	4.56
TidalVolume(mL)	552
RespirationRate(1/min)	12.9
OxygenSaturation	0.975
CarbonDioxideSaturation	0.0262
EndTidalCarbonDioxideFraction	0.0493
EndTidalCarbonDioxidePressure(mmHg)	37.4
TotalAlveolarVentilation(L/min)	5.16
TranspulmonaryPressure(cmH2O)	4.92
CoreTemperature(degC)	37.2
SkinTemperature(degC)	30.0
RespiratoryExchangeRatio	0.785
OxygenConsumptionRate(mL/min)	328
CarbonDioxideProductionRate(mL/min)	258
GlomerularFiltrationRate(mL/min)	72.3
RenalBloodFlow(L/min)	0.744
UrineProductionRate(mL/min)	0.314
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0455
RightAfferentArterioleResistance(mmHg_min/mL)	0.0455
SystemicVascularResistance(mmHg_s/mL)	1.07
Aorta-Oxygen-PartialPressure(mmHg)	92.1
Aorta-CarbonDioxide-PartialPressure(mmHg)	38.7
VenaCava-Oxygen-PartialPressure(mmHg)	31.4
VenaCava-CarbonDioxide-PartialPressure(mmHg)	46.2
RightTubules-Sodium-Concentration(g/L)	4.05
LeftTubules-Sodium-Concentration(g/L)	4.05
Oxygen-AlveolarTransfer(mL/min)	145
CarbonDioxide-AlveolarTransfer(mL/min)	-132
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	31.1
BrainVasculature-Oxygen-PartialPressure(mmHg)	31.3
MyocardiumVasculature-Inflow(mL/min)	155
BrainVasculature-Inflow(mL/min)	472
VenaCava-Inflow(mL/min)	4.44e+03
RightHeart-Inflow(mL/min)	7.76e+03
TotalHemorrhageRate(mL/s)	1.00
TotalHemorrhagedVolume(mL)	1.37e+03
BaroreceptorHeartRateScale	1.47
BaroreceptorHeartElastanceScale	0.858
BaroreceptorResistanceScale	1.12
BaroreceptorComplianceScale	0.924
ChemoreceptorHeartRateScale	0.0503
ChemoreceptorHeartElastanceScale	1.00

Segment 2

Stop the hemorrhage. Run for 600s.

Table 3. Data request validation results for Segment 2.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Segment1 (106) [157]	113		6.65%	Increase or ~Equal
MeanArterialPressure(mmHg)	EqualTo Segment1 (82.9) [157]	68.5	-17.36%		Increase or ~Equal
BloodVolume(mL)	EqualTo Segment1 (4.15e+03)	4.15e+03	-0.01%		No Change
CardiacOutput(mL/min)	EqualTo Segment1 (4.45e+03) [157]	3.92e+03	-12.04%		Increase or ~Equal
HeartStrokeVolume(mL)	EqualTo Segment1 (42.2) [157]	34.8	-17.53%		Increase or ~Equal
HemoglobinContent(g)	EqualTo Segment1 (616)	616	0.00%		No Change
RespirationRate(1/min)	EqualTo Segment1 (12.9)	13.2	2.19%		No Change

Figure 2. Vitals monitor for Segment 2.

Table 4. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	76.3
HeartRate(1/min)	106
HeartStrokeVolume(mL)	42.2
HeartEjectionFraction	0.403
BloodVolume(L)	4.15
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	82.9
SystolicArterialPressure(mmHg)	94.1
DiastolicArterialPressure(mmHg)	71.3
CardiacOutput(L/min)	4.45
HemoglobinContent(g)	616
CentralVenousPressure(mmHg)	3.17
PulmonaryCapillariesWedgePressure(mmHg)	4.56
TidalVolume(mL)	552
RespirationRate(1/min)	12.9
OxygenSaturation	0.975
CarbonDioxideSaturation	0.0262
EndTidalCarbonDioxideFraction	0.0493
EndTidalCarbonDioxidePressure(mmHg)	37.4
TotalAlveolarVentilation(L/min)	5.16
TranspulmonaryPressure(cmH2O)	4.92
CoreTemperature(degC)	37.2
SkinTemperature(degC)	30.0
RespiratoryExchangeRatio	0.785
OxygenConsumptionRate(mL/min)	328
CarbonDioxideProductionRate(mL/min)	258
GlomerularFiltrationRate(mL/min)	72.3
RenalBloodFlow(L/min)	0.744
UrineProductionRate(mL/min)	0.314
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0455
RightAfferentArterioleResistance(mmHg_min/mL)	0.0455
SystemicVascularResistance(mmHg_s/mL)	1.07
Aorta-Oxygen-PartialPressure(mmHg)	92.1
Aorta-CarbonDioxide-PartialPressure(mmHg)	38.7
VenaCava-Oxygen-PartialPressure(mmHg)	31.4
VenaCava-CarbonDioxide-PartialPressure(mmHg)	46.2
RightTubules-Sodium-Concentration(g/L)	4.05
LeftTubules-Sodium-Concentration(g/L)	4.05
Oxygen-AlveolarTransfer(mL/min)	145
CarbonDioxide-AlveolarTransfer(mL/min)	-132
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	31.1
BrainVasculature-Oxygen-PartialPressure(mmHg)	31.3
MyocardiumVasculature-Inflow(mL/min)	155
BrainVasculature-Inflow(mL/min)	472
VenaCava-Inflow(mL/min)	4.44e+03
RightHeart-Inflow(mL/min)	7.76e+03
TotalHemorrhageRate(mL/s)	1.00
TotalHemorrhagedVolume(mL)	1.37e+03
BaroreceptorHeartRateScale	1.47
BaroreceptorHeartElastanceScale	0.858
BaroreceptorResistanceScale	1.12
BaroreceptorComplianceScale	0.924
ChemoreceptorHeartRateScale	0.0503
ChemoreceptorHeartElastanceScale	1.00

Scenario Output Plots

Figure 3. Select outputs from the scenario.