HemorrhageClass2Brachial

Description

25% blood loss (class 2 hemorrhage) from the brachial artery.

Segment Validation

Segment 1

Initiate a 60 ml/min hemorrhage from the right arm. Run for 1375s.

Table 1. Data request validation results for Segment 1.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Baseline (72.0) [152]	121		68.2%	Increase
MeanArterialPressure(mmHg)	EqualTo 76 [152]	42.9	55.7%		~80% Normal
BloodVolume(mL)	EqualTo 4125	4.20e+03	1.84%		Calculated
CardiacOutput(mL/min)	[3.64e+03,3.92e+03] [152]	2.09e+03	54.1%		~65-70% Normal
HeartStrokeVolume(mL)	LessThan Baseline (80.4) [152]	17.2		-78.5%	Decrease
HemoglobinContent(g)	EqualTo 620	617	0.502%		Calculated
RespirationRate(1/min)	EqualTo Baseline (12.0) [152]	9.87	19.5%		No Change

Figure 1. Vitals monitor for Segment 1.

Table 2. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	75.8
HeartRate(1/min)	121
HeartStrokeVolume(mL)	17.2
HeartEjectionFraction	0.117
BloodVolume(L)	4.20
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	42.9
SystolicArterialPressure(mmHg)	48.1
DiastolicArterialPressure(mmHg)	38.2
CardiacOutput(L/min)	2.09
HemoglobinContent(g)	617
CentralVenousPressure(mmHg)	5.31
PulmonaryCapillariesWedgePressure(mmHg)	6.62
TidalVolume(mL)	449
RespirationRate(1/min)	9.87
OxygenSaturation	0.954
CarbonDioxideSaturation	0.0295
EndTidalCarbonDioxideFraction	0.0458
EndTidalCarbonDioxidePressure(mmHg)	34.8
TotalAlveolarVentilation(L/min)	4.43
TranspulmonaryPressure(cmH2O)	7.19
CoreTemperature(degC)	37.3
SkinTemperature(degC)	32.3
RespiratoryExchangeRatio	0.852
OxygenConsumptionRate(mL/min)	320
CarbonDioxideProductionRate(mL/min)	273
GlomerularFiltrationRate(mL/min)	2.55
RenalBloodFlow(L/min)	0.346
UrineProductionRate(mL/min)	-4.55e-17
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0531
RightAfferentArterioleResistance(mmHg_min/mL)	0.0531
SystemicVascularResistance(mmHg_s/mL)	1.08
Aorta-Oxygen-PartialPressure(mmHg)	71.2
Aorta-CarbonDioxide-PartialPressure(mmHg)	37.8
VenaCava-Oxygen-PartialPressure(mmHg)	20.7
VenaCava-CarbonDioxide-PartialPressure(mmHg)	47.8
RightTubules-Sodium-Concentration(g/L)	4.97
LeftTubules-Sodium-Concentration(g/L)	4.97
Oxygen-AlveolarTransfer(mL/min)	246
CarbonDioxide-AlveolarTransfer(mL/min)	-172
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	9.63
BrainVasculature-Oxygen-PartialPressure(mmHg)	18.9
MyocardiumVasculature-InFlow(mL/min)	80.9
BrainVasculature-InFlow(mL/min)	239
VenaCava-InFlow(mL/min)	2.12e+03
RightHeart-InFlow(mL/min)	4.36e+03
TotalHemorrhageRate(mL/s)	1.00
TotalHemorrhagedVolume(mL)	1.37e+03
BaroreceptorHeartRateScale	1.64
BaroreceptorHeartElastanceScale	0.203
BaroreceptorResistanceScale	1.13
BaroreceptorComplianceScale	0.909
ChemoreceptorHeartRateScale	4.26
ChemoreceptorHeartElastanceScale	1.00

Segment 2

Stop the hemorrhage. Run for 400s.

Table 3. Data request validation results for Segment 2.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Segment1 (121) [152]	119		-1.97%	Increase
MeanArterialPressure(mmHg)	GreaterThan Segment1 (42.9) [152]	69.8		62.7%	Increase
BloodVolume(mL)	EqualTo Segment1 (4.20e+03)	4.27e+03	1.59%		No Change
CardiacOutput(mL/min)	GreaterThan Segment1 (2.09e+03) [152]	3.68e+03		76.0%	Increase
HeartStrokeVolume(mL)	GreaterThan Segment1 (17.2) [152]	31.0		79.5%	Increase
HemoglobinContent(g)	EqualTo Segment1 (617)	617	0.000571%		No Change
RespirationRate(1/min)	EqualTo Segment1 (9.87)	13.8	33.0%		No Change

Figure 2. Vitals monitor for Segment 2.

Table 4. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	75.8
HeartRate(1/min)	121
HeartStrokeVolume(mL)	17.2
HeartEjectionFraction	0.117
BloodVolume(L)	4.20
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	42.9
SystolicArterialPressure(mmHg)	48.1
DiastolicArterialPressure(mmHg)	38.2
CardiacOutput(L/min)	2.09
HemoglobinContent(g)	617
CentralVenousPressure(mmHg)	5.31
PulmonaryCapillariesWedgePressure(mmHg)	6.62
TidalVolume(mL)	449
RespirationRate(1/min)	9.87
OxygenSaturation	0.954
CarbonDioxideSaturation	0.0295
EndTidalCarbonDioxideFraction	0.0458
EndTidalCarbonDioxidePressure(mmHg)	34.8
TotalAlveolarVentilation(L/min)	4.43
TranspulmonaryPressure(cmH2O)	7.19
CoreTemperature(degC)	37.3
SkinTemperature(degC)	32.3
RespiratoryExchangeRatio	0.852
OxygenConsumptionRate(mL/min)	320
CarbonDioxideProductionRate(mL/min)	273
GlomerularFiltrationRate(mL/min)	2.55
RenalBloodFlow(L/min)	0.346
UrineProductionRate(mL/min)	-4.55e-17
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0531
RightAfferentArterioleResistance(mmHg_min/mL)	0.0531
SystemicVascularResistance(mmHg_s/mL)	1.08
Aorta-Oxygen-PartialPressure(mmHg)	71.2
Aorta-CarbonDioxide-PartialPressure(mmHg)	37.8
VenaCava-Oxygen-PartialPressure(mmHg)	20.7
VenaCava-CarbonDioxide-PartialPressure(mmHg)	47.8
RightTubules-Sodium-Concentration(g/L)	4.97
LeftTubules-Sodium-Concentration(g/L)	4.97
Oxygen-AlveolarTransfer(mL/min)	246
CarbonDioxide-AlveolarTransfer(mL/min)	-172
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	9.63
BrainVasculature-Oxygen-PartialPressure(mmHg)	18.9
MyocardiumVasculature-InFlow(mL/min)	80.9
BrainVasculature-InFlow(mL/min)	239
VenaCava-InFlow(mL/min)	2.12e+03
RightHeart-InFlow(mL/min)	4.36e+03
TotalHemorrhageRate(mL/s)	1.00
TotalHemorrhagedVolume(mL)	1.37e+03
BaroreceptorHeartRateScale	1.64
BaroreceptorHeartElastanceScale	0.203
BaroreceptorResistanceScale	1.13
BaroreceptorComplianceScale	0.909
ChemoreceptorHeartRateScale	4.26
ChemoreceptorHeartElastanceScale	1.00

Scenario Output Plots

Figure 3. Select outputs from the scenario.