Hemorrhage-Class2InternalSpleen

HemorrhageClass2InternalSpleen

Description

25% blood loss (class 2 hemorrhage) internally from the spleen.

Segment Validation

Segment 1

Initiate a 60 ml/min hemorrhage from the spleen. Run for 1230s.

Table 1. Data request validation results for Segment 1.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Baseline (72.0) [157]	94.6		31.34%	Increase
MeanArterialPressure(mmHg)	LessThan Baseline (95.3) [157]	92.4		-2.97%	65-90%
BloodVolume(mL)	EqualTo Baseline - 1230 (4.26e+03)	4.30e+03	1.00%		Calculated
CardiacOutput(mL/min)	LessThan Baseline (5.78e+03) [157]	4.85e+03		-16.03%	50-90%
HeartStrokeVolume(mL)	LessThan Baseline (80.2) [157]	51.3		-36.07%	Decrease
HemoglobinContent(g)	EqualTo 620	638	2.89%		Calculated
RespirationRate(1/min)	EqualTo Baseline (11.9) [157]	12.6	5.44%		No Change

Figure 1. Vitals monitor for Segment 1.

Table 2. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	76.5
HeartRate(1/min)	94.6
HeartStrokeVolume(mL)	51.3
HeartEjectionFraction	0.465
BloodVolume(L)	4.30
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	92.4
SystolicArterialPressure(mmHg)	106
DiastolicArterialPressure(mmHg)	78.1
CardiacOutput(L/min)	4.85
HemoglobinContent(g)	638
CentralVenousPressure(mmHg)	3.30
PulmonaryCapillariesWedgePressure(mmHg)	4.85
TidalVolume(mL)	536
RespirationRate(1/min)	12.6
OxygenSaturation	0.976
CarbonDioxideSaturation	0.0262
EndTidalCarbonDioxideFraction	0.0492
EndTidalCarbonDioxidePressure(mmHg)	37.4
TotalAlveolarVentilation(L/min)	4.83
TranspulmonaryPressure(cmH2O)	7.75
CoreTemperature(degC)	37.1
SkinTemperature(degC)	30.2
RespiratoryExchangeRatio	0.791
OxygenConsumptionRate(mL/min)	307
CarbonDioxideProductionRate(mL/min)	243
GlomerularFiltrationRate(mL/min)	86.1
RenalBloodFlow(L/min)	0.799
UrineProductionRate(mL/min)	0.687
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0463
RightAfferentArterioleResistance(mmHg_min/mL)	0.0463
SystemicVascularResistance(mmHg_s/mL)	1.10
Aorta-Oxygen-PartialPressure(mmHg)	93.8
Aorta-CarbonDioxide-PartialPressure(mmHg)	38.6
VenaCava-Oxygen-PartialPressure(mmHg)	33.7
VenaCava-CarbonDioxide-PartialPressure(mmHg)	45.6
RightTubules-Sodium-Concentration(g/L)	4.03
LeftTubules-Sodium-Concentration(g/L)	4.03
Oxygen-AlveolarTransfer(mL/min)	143
CarbonDioxide-AlveolarTransfer(mL/min)	-139
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	34.4
BrainVasculature-Oxygen-PartialPressure(mmHg)	33.7
MyocardiumVasculature-Inflow(mL/min)	163
BrainVasculature-Inflow(mL/min)	498
VenaCava-Inflow(mL/min)	4.71e+03
RightHeart-Inflow(mL/min)	8.28e+03
TotalHemorrhageRate(mL/s)	1.00
TotalHemorrhagedVolume(mL)	1.23e+03
BaroreceptorHeartRateScale	1.32
BaroreceptorHeartElastanceScale	1.01
BaroreceptorResistanceScale	1.18
BaroreceptorComplianceScale	0.909
ChemoreceptorHeartRateScale	0.0256
ChemoreceptorHeartElastanceScale	1.00

Segment 2

Stop the hemorrhage. Run for 600s.

Table 3. Data request validation results for Segment 2.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Segment1 (94.6) [157]	112		17.90%	Increase or ~Equal
MeanArterialPressure(mmHg)	EqualTo Segment1 (92.4) [157]	70.8	-23.37%		Increase or ~Equal
BloodVolume(mL)	EqualTo Segment1 (4.30e+03)	4.30e+03	-0.09%		No Change
CardiacOutput(mL/min)	EqualTo Segment1 (4.85e+03) [157]	3.95e+03	-18.67%		Increase or ~Equal
HeartStrokeVolume(mL)	EqualTo Segment1 (51.3) [157]	35.4	-31.02%		Increase or ~Equal
HemoglobinContent(g)	EqualTo Segment1 (638)	638	0.00%		No Change
RespirationRate(1/min)	EqualTo Segment1 (12.6)	12.8	1.70%		No Change

Figure 2. Vitals monitor for Segment 2.

Table 4. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	76.5
HeartRate(1/min)	94.6
HeartStrokeVolume(mL)	51.3
HeartEjectionFraction	0.465
BloodVolume(L)	4.30
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	92.4
SystolicArterialPressure(mmHg)	106
DiastolicArterialPressure(mmHg)	78.1
CardiacOutput(L/min)	4.85
HemoglobinContent(g)	638
CentralVenousPressure(mmHg)	3.30
PulmonaryCapillariesWedgePressure(mmHg)	4.85
TidalVolume(mL)	536
RespirationRate(1/min)	12.6
OxygenSaturation	0.976
CarbonDioxideSaturation	0.0262
EndTidalCarbonDioxideFraction	0.0492
EndTidalCarbonDioxidePressure(mmHg)	37.4
TotalAlveolarVentilation(L/min)	4.83
TranspulmonaryPressure(cmH2O)	7.75
CoreTemperature(degC)	37.1
SkinTemperature(degC)	30.2
RespiratoryExchangeRatio	0.791
OxygenConsumptionRate(mL/min)	307
CarbonDioxideProductionRate(mL/min)	243
GlomerularFiltrationRate(mL/min)	86.1
RenalBloodFlow(L/min)	0.799
UrineProductionRate(mL/min)	0.687
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0463
RightAfferentArterioleResistance(mmHg_min/mL)	0.0463
SystemicVascularResistance(mmHg_s/mL)	1.10
Aorta-Oxygen-PartialPressure(mmHg)	93.8
Aorta-CarbonDioxide-PartialPressure(mmHg)	38.6
VenaCava-Oxygen-PartialPressure(mmHg)	33.7
VenaCava-CarbonDioxide-PartialPressure(mmHg)	45.6
RightTubules-Sodium-Concentration(g/L)	4.03
LeftTubules-Sodium-Concentration(g/L)	4.03
Oxygen-AlveolarTransfer(mL/min)	143
CarbonDioxide-AlveolarTransfer(mL/min)	-139
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	34.4
BrainVasculature-Oxygen-PartialPressure(mmHg)	33.7
MyocardiumVasculature-Inflow(mL/min)	163
BrainVasculature-Inflow(mL/min)	498
VenaCava-Inflow(mL/min)	4.71e+03
RightHeart-Inflow(mL/min)	8.28e+03
TotalHemorrhageRate(mL/s)	1.00
TotalHemorrhagedVolume(mL)	1.23e+03
BaroreceptorHeartRateScale	1.32
BaroreceptorHeartElastanceScale	1.01
BaroreceptorResistanceScale	1.18
BaroreceptorComplianceScale	0.909
ChemoreceptorHeartRateScale	0.0256
ChemoreceptorHeartElastanceScale	1.00

Scenario Output Plots

Figure 3. Select outputs from the scenario.