HemorrhageClass2InternalSpleen

Description

25% blood loss (class 2 hemorrhage) internally from the spleen.

Segment Validation

Segment 1

Initiate a 60 ml/min hemorrhage from the spleen. Run for 1230s.

Table 1. Data request validation results for Segment 1.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Baseline (72.0) [152]	101		40.3%	Increase
MeanArterialPressure(mmHg)	EqualTo 76 [152]	93.6	20.7%		~80% Normal
BloodVolume(mL)	EqualTo 4300	4.33e+03	0.629%		Calculated
CardiacOutput(mL/min)	[3.64e+03,3.92e+03] [152]	4.64e+03	16.9%		~65-70% Normal
HeartStrokeVolume(mL)	LessThan Baseline (80.4) [152]	46.0		-42.8%	Decrease
HemoglobinContent(g)	EqualTo 630	638	1.33%		Calculated
RespirationRate(1/min)	EqualTo Baseline (12.0) [152]	12.8	6.19%		No Change

Figure 1. Vitals monitor for Segment 1.

Table 2. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	76.4
HeartRate(1/min)	101
HeartStrokeVolume(mL)	46.0
HeartEjectionFraction	0.439
BloodVolume(L)	4.33
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	93.6
SystolicArterialPressure(mmHg)	106
DiastolicArterialPressure(mmHg)	80.7
CardiacOutput(L/min)	4.64
HemoglobinContent(g)	638
CentralVenousPressure(mmHg)	3.48
PulmonaryCapillariesWedgePressure(mmHg)	4.57
TidalVolume(mL)	577
RespirationRate(1/min)	12.8
OxygenSaturation	0.968
CarbonDioxideSaturation	0.0285
EndTidalCarbonDioxideFraction	0.0486
EndTidalCarbonDioxidePressure(mmHg)	36.9
TotalAlveolarVentilation(L/min)	7.36
TranspulmonaryPressure(cmH2O)	4.89
CoreTemperature(degC)	37.3
SkinTemperature(degC)	32.4
RespiratoryExchangeRatio	0.800
OxygenConsumptionRate(mL/min)	307
CarbonDioxideProductionRate(mL/min)	246
GlomerularFiltrationRate(mL/min)	101
RenalBloodFlow(L/min)	0.819
UrineProductionRate(mL/min)	0.428
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0596
RightAfferentArterioleResistance(mmHg_min/mL)	0.0596
SystemicVascularResistance(mmHg_s/mL)	1.16
Aorta-Oxygen-PartialPressure(mmHg)	83.4
Aorta-CarbonDioxide-PartialPressure(mmHg)	40.5
VenaCava-Oxygen-PartialPressure(mmHg)	31.8
VenaCava-CarbonDioxide-PartialPressure(mmHg)	45.6
RightTubules-Sodium-Concentration(g/L)	5.15
LeftTubules-Sodium-Concentration(g/L)	5.15
Oxygen-AlveolarTransfer(mL/min)	296
CarbonDioxide-AlveolarTransfer(mL/min)	-199
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	32.3
BrainVasculature-Oxygen-PartialPressure(mmHg)	32.1
MyocardiumVasculature-InFlow(mL/min)	183
BrainVasculature-InFlow(mL/min)	535
VenaCava-InFlow(mL/min)	4.58e+03
RightHeart-InFlow(mL/min)	1.11e+04
TotalHemorrhageRate(mL/s)	1.00
TotalHemorrhagedVolume(mL)	1.23e+03
BaroreceptorHeartRateScale	1.41
BaroreceptorHeartElastanceScale	1.02
BaroreceptorResistanceScale	1.24
BaroreceptorComplianceScale	0.883
ChemoreceptorHeartRateScale	0.277
ChemoreceptorHeartElastanceScale	1.00

Segment 2

Stop the hemorrhage. Run for 400s.

Table 3. Data request validation results for Segment 2.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Segment1 (101) [152]	99.7		-1.28%	Increase
MeanArterialPressure(mmHg)	GreaterThan Segment1 (93.6) [152]	93.7		0.177%	Increase
BloodVolume(mL)	EqualTo Segment1 (4.33e+03)	4.35e+03	0.607%		No Change
CardiacOutput(mL/min)	GreaterThan Segment1 (4.64e+03) [152]	4.60e+03		-0.984%	Increase
HeartStrokeVolume(mL)	GreaterThan Segment1 (46.0) [152]	46.1		0.301%	Increase
HemoglobinContent(g)	EqualTo Segment1 (638)	638	0.000346%		No Change
RespirationRate(1/min)	EqualTo Segment1 (12.8)	13.0	1.72%		No Change

Figure 2. Vitals monitor for Segment 2.

Table 4. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	76.4
HeartRate(1/min)	101
HeartStrokeVolume(mL)	46.0
HeartEjectionFraction	0.439
BloodVolume(L)	4.33
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	93.6
SystolicArterialPressure(mmHg)	106
DiastolicArterialPressure(mmHg)	80.7
CardiacOutput(L/min)	4.64
HemoglobinContent(g)	638
CentralVenousPressure(mmHg)	3.48
PulmonaryCapillariesWedgePressure(mmHg)	4.57
TidalVolume(mL)	577
RespirationRate(1/min)	12.8
OxygenSaturation	0.968
CarbonDioxideSaturation	0.0285
EndTidalCarbonDioxideFraction	0.0486
EndTidalCarbonDioxidePressure(mmHg)	36.9
TotalAlveolarVentilation(L/min)	7.36
TranspulmonaryPressure(cmH2O)	4.89
CoreTemperature(degC)	37.3
SkinTemperature(degC)	32.4
RespiratoryExchangeRatio	0.800
OxygenConsumptionRate(mL/min)	307
CarbonDioxideProductionRate(mL/min)	246
GlomerularFiltrationRate(mL/min)	101
RenalBloodFlow(L/min)	0.819
UrineProductionRate(mL/min)	0.428
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0596
RightAfferentArterioleResistance(mmHg_min/mL)	0.0596
SystemicVascularResistance(mmHg_s/mL)	1.16
Aorta-Oxygen-PartialPressure(mmHg)	83.4
Aorta-CarbonDioxide-PartialPressure(mmHg)	40.5
VenaCava-Oxygen-PartialPressure(mmHg)	31.8
VenaCava-CarbonDioxide-PartialPressure(mmHg)	45.6
RightTubules-Sodium-Concentration(g/L)	5.15
LeftTubules-Sodium-Concentration(g/L)	5.15
Oxygen-AlveolarTransfer(mL/min)	296
CarbonDioxide-AlveolarTransfer(mL/min)	-199
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	32.3
BrainVasculature-Oxygen-PartialPressure(mmHg)	32.1
MyocardiumVasculature-InFlow(mL/min)	183
BrainVasculature-InFlow(mL/min)	535
VenaCava-InFlow(mL/min)	4.58e+03
RightHeart-InFlow(mL/min)	1.11e+04
TotalHemorrhageRate(mL/s)	1.00
TotalHemorrhagedVolume(mL)	1.23e+03
BaroreceptorHeartRateScale	1.41
BaroreceptorHeartElastanceScale	1.02
BaroreceptorResistanceScale	1.24
BaroreceptorComplianceScale	0.883
ChemoreceptorHeartRateScale	0.277
ChemoreceptorHeartElastanceScale	1.00

Scenario Output Plots

Figure 3. Select outputs from the scenario.