Hemorrhage-Class2Saline
HemorrhageClass2Saline
Description
25% blood loss (class 2 hemorrhage) then intravenous administration of saline.
Segment Validation
Segment 1
Initiate a 90 ml/min hemorrhage from the right arm. Initiate a 50 ml/min hemorrhage from the vena cava. Run for 590s.
| Property Name | Validation | Engine Value | Percent Error | Percent Change | Notes |
|---|---|---|---|---|---|
| HeartRate(1/min) | GreaterThan Baseline (72.0) [152] | 112 | 56.0% | Increase | |
| MeanArterialPressure(mmHg) | EqualTo 76 [152] | 88.3 | 15.0% | ~80% Normal | |
| BloodVolume(mL) | EqualTo 4190 | 4.14e+03 | 1.08% | Calculated | |
| CardiacOutput(mL/min) | [3.64e+03,3.92e+03] [152] | 4.27e+03 | 8.56% | ~65-70% Normal | |
| HeartStrokeVolume(mL) | LessThan Baseline (80.4) [152] | 38.0 | -52.7% | Decrease | |
| HemoglobinContent(g) | EqualTo 630 | 616 | 2.27% | Calculated | |
| RespirationRate(1/min) | EqualTo Baseline (12.0) [152] | 12.8 | 6.61% | No Change |
 |
| Property Name | Engine Value |
|---|---|
| Patient-Weight(kg) | 76.2 |
| HeartRate(1/min) | 112 |
| HeartStrokeVolume(mL) | 38.0 |
| HeartEjectionFraction | 0.399 |
| BloodVolume(L) | 4.14 |
| ExtravascularFluidVolume(L) | 34.1 |
| MeanArterialPressure(mmHg) | 88.3 |
| SystolicArterialPressure(mmHg) | 98.5 |
| DiastolicArterialPressure(mmHg) | 77.6 |
| CardiacOutput(L/min) | 4.27 |
| HemoglobinContent(g) | 616 |
| CentralVenousPressure(mmHg) | 3.14 |
| PulmonaryCapillariesWedgePressure(mmHg) | 4.09 |
| TidalVolume(mL) | 578 |
| RespirationRate(1/min) | 12.8 |
| OxygenSaturation | 0.965 |
| CarbonDioxideSaturation | 0.0285 |
| EndTidalCarbonDioxideFraction | 0.0486 |
| EndTidalCarbonDioxidePressure(mmHg) | 37.0 |
| TotalAlveolarVentilation(L/min) | 7.41 |
| TranspulmonaryPressure(cmH2O) | 6.29 |
| CoreTemperature(degC) | 37.2 |
| SkinTemperature(degC) | 32.7 |
| RespiratoryExchangeRatio | 0.793 |
| OxygenConsumptionRate(mL/min) | 324 |
| CarbonDioxideProductionRate(mL/min) | 257 |
| GlomerularFiltrationRate(mL/min) | 84.0 |
| RenalBloodFlow(L/min) | 0.709 |
| UrineProductionRate(mL/min) | 0.105 |
| LeftAfferentArterioleResistance(mmHg_min/mL) | 0.0502 |
| RightAfferentArterioleResistance(mmHg_min/mL) | 0.0502 |
| SystemicVascularResistance(mmHg_s/mL) | 1.20 |
| Aorta-Oxygen-PartialPressure(mmHg) | 80.8 |
| Aorta-CarbonDioxide-PartialPressure(mmHg) | 40.6 |
| VenaCava-Oxygen-PartialPressure(mmHg) | 29.7 |
| VenaCava-CarbonDioxide-PartialPressure(mmHg) | 45.9 |
| RightTubules-Sodium-Concentration(g/L) | 4.74 |
| LeftTubules-Sodium-Concentration(g/L) | 4.74 |
| Oxygen-AlveolarTransfer(mL/min) | 264 |
| CarbonDioxide-AlveolarTransfer(mL/min) | -182 |
| MyocardiumVasculature-Oxygen-PartialPressure(mmHg) | 29.3 |
| BrainVasculature-Oxygen-PartialPressure(mmHg) | 28.6 |
| MyocardiumVasculature-InFlow(mL/min) | 142 |
| BrainVasculature-InFlow(mL/min) | 436 |
| VenaCava-InFlow(mL/min) | 4.16e+03 |
| RightHeart-InFlow(mL/min) | 42.6 |
| TotalHemorrhageRate(mL/s) | 2.33 |
| TotalHemorrhagedVolume(mL) | 1.38e+03 |
| BaroreceptorHeartRateScale | 1.57 |
| BaroreceptorHeartElastanceScale | 1.00 |
| BaroreceptorResistanceScale | 1.29 |
| BaroreceptorComplianceScale | 0.861 |
| ChemoreceptorHeartRateScale | 0.509 |
| ChemoreceptorHeartElastanceScale | 1.00 |
Segment 2
Stop the hemorrhages. Run for 120s.
| Property Name | Validation | Engine Value | Percent Error | Percent Change | Notes |
|---|---|---|---|---|---|
| HeartRate(1/min) | LessThan Segment1 (112) [152] | 113 | 0.405% | Increase | |
| MeanArterialPressure(mmHg) | GreaterThan Segment1 (88.3) [152] | 89.1 | 0.811% | Increase | |
| BloodVolume(mL) | EqualTo Segment1 (4.14e+03) | 4.16e+03 | 0.245% | No Change | |
| CardiacOutput(mL/min) | GreaterThan Segment1 (4.27e+03) [152] | 4.31e+03 | 0.848% | Increase | |
| HeartStrokeVolume(mL) | GreaterThan Segment1 (38.0) [152] | 38.2 | 0.442% | Increase | |
| HemoglobinContent(g) | EqualTo Segment1 (616) | 616 | 0.000101% | No Change | |
| RespirationRate(1/min) | EqualTo Segment1 (12.8) | 13.1 | 2.16% | No Change |
 |
| Property Name | Engine Value |
|---|---|
| Patient-Weight(kg) | 76.2 |
| HeartRate(1/min) | 112 |
| HeartStrokeVolume(mL) | 38.0 |
| HeartEjectionFraction | 0.399 |
| BloodVolume(L) | 4.14 |
| ExtravascularFluidVolume(L) | 34.1 |
| MeanArterialPressure(mmHg) | 88.3 |
| SystolicArterialPressure(mmHg) | 98.5 |
| DiastolicArterialPressure(mmHg) | 77.6 |
| CardiacOutput(L/min) | 4.27 |
| HemoglobinContent(g) | 616 |
| CentralVenousPressure(mmHg) | 3.14 |
| PulmonaryCapillariesWedgePressure(mmHg) | 4.09 |
| TidalVolume(mL) | 578 |
| RespirationRate(1/min) | 12.8 |
| OxygenSaturation | 0.965 |
| CarbonDioxideSaturation | 0.0285 |
| EndTidalCarbonDioxideFraction | 0.0486 |
| EndTidalCarbonDioxidePressure(mmHg) | 37.0 |
| TotalAlveolarVentilation(L/min) | 7.41 |
| TranspulmonaryPressure(cmH2O) | 6.29 |
| CoreTemperature(degC) | 37.2 |
| SkinTemperature(degC) | 32.7 |
| RespiratoryExchangeRatio | 0.793 |
| OxygenConsumptionRate(mL/min) | 324 |
| CarbonDioxideProductionRate(mL/min) | 257 |
| GlomerularFiltrationRate(mL/min) | 84.0 |
| RenalBloodFlow(L/min) | 0.709 |
| UrineProductionRate(mL/min) | 0.105 |
| LeftAfferentArterioleResistance(mmHg_min/mL) | 0.0502 |
| RightAfferentArterioleResistance(mmHg_min/mL) | 0.0502 |
| SystemicVascularResistance(mmHg_s/mL) | 1.20 |
| Aorta-Oxygen-PartialPressure(mmHg) | 80.8 |
| Aorta-CarbonDioxide-PartialPressure(mmHg) | 40.6 |
| VenaCava-Oxygen-PartialPressure(mmHg) | 29.7 |
| VenaCava-CarbonDioxide-PartialPressure(mmHg) | 45.9 |
| RightTubules-Sodium-Concentration(g/L) | 4.74 |
| LeftTubules-Sodium-Concentration(g/L) | 4.74 |
| Oxygen-AlveolarTransfer(mL/min) | 264 |
| CarbonDioxide-AlveolarTransfer(mL/min) | -182 |
| MyocardiumVasculature-Oxygen-PartialPressure(mmHg) | 29.3 |
| BrainVasculature-Oxygen-PartialPressure(mmHg) | 28.6 |
| MyocardiumVasculature-InFlow(mL/min) | 142 |
| BrainVasculature-InFlow(mL/min) | 436 |
| VenaCava-InFlow(mL/min) | 4.16e+03 |
| RightHeart-InFlow(mL/min) | 42.6 |
| TotalHemorrhageRate(mL/s) | 2.33 |
| TotalHemorrhagedVolume(mL) | 1.38e+03 |
| BaroreceptorHeartRateScale | 1.57 |
| BaroreceptorHeartElastanceScale | 1.00 |
| BaroreceptorResistanceScale | 1.29 |
| BaroreceptorComplianceScale | 0.861 |
| ChemoreceptorHeartRateScale | 0.509 |
| ChemoreceptorHeartElastanceScale | 1.00 |
Segment 3
Provide an IV with saline at 100 mL/min with a 500 mL bag. Run for 400s.
| Property Name | Validation | Engine Value | Percent Error | Percent Change | Notes |
|---|---|---|---|---|---|
| HeartRate(1/min) | LessThan Segment2 (113) [245] | 93.5 | -17.2% | Decrease | |
| MeanArterialPressure(mmHg) | GreaterThan Segment2 (89.1) [152] | 94.1 | 5.68% | Increase | |
| BloodVolume(mL) | EqualTo 4590 | 4.68e+03 | 2.00% | Calculated | |
| CardiacOutput(mL/min) | GreaterThan Segment2 (4.31e+03) [152] | 4.82e+03 | 11.9% | Increase | |
| HeartStrokeVolume(mL) | GreaterThan Segment2 (38.2) [152] | 51.5 | 35.0% | Increase | |
| HemoglobinContent(g) | EqualTo Segment2 (616) | 616 | 0.000702% | No Change | |
| RespirationRate(1/min) | EqualTo Segment2 (13.1) | 12.8 | 2.59% | No Change |
 |
| Property Name | Engine Value |
|---|---|
| Patient-Weight(kg) | 76.2 |
| HeartRate(1/min) | 112 |
| HeartStrokeVolume(mL) | 38.0 |
| HeartEjectionFraction | 0.399 |
| BloodVolume(L) | 4.14 |
| ExtravascularFluidVolume(L) | 34.1 |
| MeanArterialPressure(mmHg) | 88.3 |
| SystolicArterialPressure(mmHg) | 98.5 |
| DiastolicArterialPressure(mmHg) | 77.6 |
| CardiacOutput(L/min) | 4.27 |
| HemoglobinContent(g) | 616 |
| CentralVenousPressure(mmHg) | 3.14 |
| PulmonaryCapillariesWedgePressure(mmHg) | 4.09 |
| TidalVolume(mL) | 578 |
| RespirationRate(1/min) | 12.8 |
| OxygenSaturation | 0.965 |
| CarbonDioxideSaturation | 0.0285 |
| EndTidalCarbonDioxideFraction | 0.0486 |
| EndTidalCarbonDioxidePressure(mmHg) | 37.0 |
| TotalAlveolarVentilation(L/min) | 7.41 |
| TranspulmonaryPressure(cmH2O) | 6.29 |
| CoreTemperature(degC) | 37.2 |
| SkinTemperature(degC) | 32.7 |
| RespiratoryExchangeRatio | 0.793 |
| OxygenConsumptionRate(mL/min) | 324 |
| CarbonDioxideProductionRate(mL/min) | 257 |
| GlomerularFiltrationRate(mL/min) | 84.0 |
| RenalBloodFlow(L/min) | 0.709 |
| UrineProductionRate(mL/min) | 0.105 |
| LeftAfferentArterioleResistance(mmHg_min/mL) | 0.0502 |
| RightAfferentArterioleResistance(mmHg_min/mL) | 0.0502 |
| SystemicVascularResistance(mmHg_s/mL) | 1.20 |
| Aorta-Oxygen-PartialPressure(mmHg) | 80.8 |
| Aorta-CarbonDioxide-PartialPressure(mmHg) | 40.6 |
| VenaCava-Oxygen-PartialPressure(mmHg) | 29.7 |
| VenaCava-CarbonDioxide-PartialPressure(mmHg) | 45.9 |
| RightTubules-Sodium-Concentration(g/L) | 4.74 |
| LeftTubules-Sodium-Concentration(g/L) | 4.74 |
| Oxygen-AlveolarTransfer(mL/min) | 264 |
| CarbonDioxide-AlveolarTransfer(mL/min) | -182 |
| MyocardiumVasculature-Oxygen-PartialPressure(mmHg) | 29.3 |
| BrainVasculature-Oxygen-PartialPressure(mmHg) | 28.6 |
| MyocardiumVasculature-InFlow(mL/min) | 142 |
| BrainVasculature-InFlow(mL/min) | 436 |
| VenaCava-InFlow(mL/min) | 4.16e+03 |
| RightHeart-InFlow(mL/min) | 42.6 |
| TotalHemorrhageRate(mL/s) | 2.33 |
| TotalHemorrhagedVolume(mL) | 1.38e+03 |
| BaroreceptorHeartRateScale | 1.57 |
| BaroreceptorHeartElastanceScale | 1.00 |
| BaroreceptorResistanceScale | 1.29 |
| BaroreceptorComplianceScale | 0.861 |
| ChemoreceptorHeartRateScale | 0.509 |
| ChemoreceptorHeartElastanceScale | 1.00 |
Scenario Output Plots
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