HemorrhageClass3NoFluid

Description

35% blood loss (class 3 hemorrhage).

Segment Validation

Segment 1

Initiate a 75 ml/min hemorrhage from the right arm. Initiate a 125 ml/min hemorrhage from the vena cava. Run for 575s.

Table 1. Data request validation results for Segment 1.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Baseline (72.0) [152]	126		75.6%	Increase
MeanArterialPressure(mmHg)	EqualTo 47.5 [152]	42.9	10.2%		~50% Normal
BloodVolume(mL)	EqualTo 3600	3.62e+03	0.498%		Calculated
CardiacOutput(mL/min)	EqualTo 2800 [152]	2.07e+03	29.8%		~50% Normal
HeartStrokeVolume(mL)	LessThan Baseline (80.4) [152]	16.4		-79.6%	Decrease
HemoglobinContent(g)	EqualTo 575	535	7.13%		Calculated
RespirationRate(1/min)	GreaterThan Baseline (12.0) [152]	12.1		0.806%	Increase

Figure 1. Vitals monitor for Segment 1.

Table 2. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	75.6
HeartRate(1/min)	126
HeartStrokeVolume(mL)	16.4
HeartEjectionFraction	0.140
BloodVolume(L)	3.62
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	42.9
SystolicArterialPressure(mmHg)	47.9
DiastolicArterialPressure(mmHg)	38.4
CardiacOutput(L/min)	2.07
HemoglobinContent(g)	535
CentralVenousPressure(mmHg)	3.96
PulmonaryCapillariesWedgePressure(mmHg)	5.10
TidalVolume(mL)	540
RespirationRate(1/min)	12.1
OxygenSaturation	0.956
CarbonDioxideSaturation	0.0303
EndTidalCarbonDioxideFraction	0.0410
EndTidalCarbonDioxidePressure(mmHg)	31.2
TotalAlveolarVentilation(L/min)	6.54
TranspulmonaryPressure(cmH2O)	4.91
CoreTemperature(degC)	37.2
SkinTemperature(degC)	32.6
RespiratoryExchangeRatio	0.847
OxygenConsumptionRate(mL/min)	334
CarbonDioxideProductionRate(mL/min)	283
GlomerularFiltrationRate(mL/min)	10.7
RenalBloodFlow(L/min)	0.373
UrineProductionRate(mL/min)	-4.55e-17
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0418
RightAfferentArterioleResistance(mmHg_min/mL)	0.0418
SystemicVascularResistance(mmHg_s/mL)	1.13
Aorta-Oxygen-PartialPressure(mmHg)	70.4
Aorta-CarbonDioxide-PartialPressure(mmHg)	35.9
VenaCava-Oxygen-PartialPressure(mmHg)	20.2
VenaCava-CarbonDioxide-PartialPressure(mmHg)	47.9
RightTubules-Sodium-Concentration(g/L)	4.75
LeftTubules-Sodium-Concentration(g/L)	4.75
Oxygen-AlveolarTransfer(mL/min)	246
CarbonDioxide-AlveolarTransfer(mL/min)	-166
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	9.83
BrainVasculature-Oxygen-PartialPressure(mmHg)	14.7
MyocardiumVasculature-InFlow(mL/min)	80.7
BrainVasculature-InFlow(mL/min)	238
VenaCava-InFlow(mL/min)	2.21e+03
RightHeart-InFlow(mL/min)	4.35e+03
TotalHemorrhageRate(mL/s)	3.33
TotalHemorrhagedVolume(mL)	1.92e+03
BaroreceptorHeartRateScale	1.71
BaroreceptorHeartElastanceScale	0.270
BaroreceptorResistanceScale	1.18
BaroreceptorComplianceScale	0.899
ChemoreceptorHeartRateScale	5.07
ChemoreceptorHeartElastanceScale	1.00

Segment 2

Stop the hemorrhages. Run for 500s.

Table 3. Data request validation results for Segment 2.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Segment1 (126) [152]	127		0.137%	Increase
MeanArterialPressure(mmHg)	GreaterThan Segment1 (42.9) [152]	64.7		50.9%	Increase
BloodVolume(mL)	EqualTo Segment1 (3.62e+03)	3.71e+03	2.51%		No Change
CardiacOutput(mL/min)	GreaterThan Segment1 (2.07e+03) [152]	3.37e+03		62.4%	Increase
HeartStrokeVolume(mL)	GreaterThan Segment1 (16.4) [152]	26.6		62.2%	Increase
HemoglobinContent(g)	EqualTo Segment1 (535)	535	0.000219%		No Change
RespirationRate(1/min)	EqualTo Segment1 (12.1)	13.8	12.9%		No Change

Figure 2. Vitals monitor for Segment 2.

Table 4. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	75.6
HeartRate(1/min)	126
HeartStrokeVolume(mL)	16.4
HeartEjectionFraction	0.140
BloodVolume(L)	3.62
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	42.9
SystolicArterialPressure(mmHg)	47.9
DiastolicArterialPressure(mmHg)	38.4
CardiacOutput(L/min)	2.07
HemoglobinContent(g)	535
CentralVenousPressure(mmHg)	3.96
PulmonaryCapillariesWedgePressure(mmHg)	5.10
TidalVolume(mL)	540
RespirationRate(1/min)	12.1
OxygenSaturation	0.956
CarbonDioxideSaturation	0.0303
EndTidalCarbonDioxideFraction	0.0410
EndTidalCarbonDioxidePressure(mmHg)	31.2
TotalAlveolarVentilation(L/min)	6.54
TranspulmonaryPressure(cmH2O)	4.91
CoreTemperature(degC)	37.2
SkinTemperature(degC)	32.6
RespiratoryExchangeRatio	0.847
OxygenConsumptionRate(mL/min)	334
CarbonDioxideProductionRate(mL/min)	283
GlomerularFiltrationRate(mL/min)	10.7
RenalBloodFlow(L/min)	0.373
UrineProductionRate(mL/min)	-4.55e-17
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0418
RightAfferentArterioleResistance(mmHg_min/mL)	0.0418
SystemicVascularResistance(mmHg_s/mL)	1.13
Aorta-Oxygen-PartialPressure(mmHg)	70.4
Aorta-CarbonDioxide-PartialPressure(mmHg)	35.9
VenaCava-Oxygen-PartialPressure(mmHg)	20.2
VenaCava-CarbonDioxide-PartialPressure(mmHg)	47.9
RightTubules-Sodium-Concentration(g/L)	4.75
LeftTubules-Sodium-Concentration(g/L)	4.75
Oxygen-AlveolarTransfer(mL/min)	246
CarbonDioxide-AlveolarTransfer(mL/min)	-166
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	9.83
BrainVasculature-Oxygen-PartialPressure(mmHg)	14.7
MyocardiumVasculature-InFlow(mL/min)	80.7
BrainVasculature-InFlow(mL/min)	238
VenaCava-InFlow(mL/min)	2.21e+03
RightHeart-InFlow(mL/min)	4.35e+03
TotalHemorrhageRate(mL/s)	3.33
TotalHemorrhagedVolume(mL)	1.92e+03
BaroreceptorHeartRateScale	1.71
BaroreceptorHeartElastanceScale	0.270
BaroreceptorResistanceScale	1.18
BaroreceptorComplianceScale	0.899
ChemoreceptorHeartRateScale	5.07
ChemoreceptorHeartElastanceScale	1.00

Scenario Output Plots

Figure 3. Select outputs from the scenario.