Hemorrhage-Class3PackedRedBloodCells
HemorrhageClass3PackedBloodCells
Description
30% blood loss (class 3 hemorrhage) then intravenous administration of packed red blood cells.
Segment Validation
Segment 1
Initiate a 75 ml/min hemorrhage from the right arm. Initiate a 175 ml/min hemorrhage from the vena cava. Run for 400s.
| Property Name | Validation | Engine Value | Percent Error | Percent Change | Notes |
|---|---|---|---|---|---|
| HeartRate(1/min) | GreaterThan Baseline (72.0) [152] | 119 | 64.8% | Increase | |
| MeanArterialPressure(mmHg) | EqualTo 57 [152] | 69.1 | 19.2% | ~60% Normal | |
| BloodVolume(mL) | EqualTo 3800 | 3.85e+03 | 1.29% | Calculated | |
| CardiacOutput(mL/min) | EqualTo 2800 [152] | 3.44e+03 | 20.6% | ~50% Normal | |
| HeartStrokeVolume(mL) | LessThan Baseline (80.4) [152] | 29.0 | -63.9% | Decrease | |
| HemoglobinContent(g) | EqualTo 575 | 572 | 0.447% | Calculated | |
| RespirationRate(1/min) | GreaterThan Baseline (12.0) [152] | 12.7 | 5.49% | Increase |
 |
| Property Name | Engine Value |
|---|---|
| Patient-Weight(kg) | 76.0 |
| HeartRate(1/min) | 119 |
| HeartStrokeVolume(mL) | 29.0 |
| HeartEjectionFraction | 0.312 |
| BloodVolume(L) | 3.85 |
| ExtravascularFluidVolume(L) | 34.1 |
| MeanArterialPressure(mmHg) | 69.1 |
| SystolicArterialPressure(mmHg) | 77.5 |
| DiastolicArterialPressure(mmHg) | 61.2 |
| CardiacOutput(L/min) | 3.44 |
| HemoglobinContent(g) | 572 |
| CentralVenousPressure(mmHg) | 3.13 |
| PulmonaryCapillariesWedgePressure(mmHg) | 3.96 |
| TidalVolume(mL) | 570 |
| RespirationRate(1/min) | 12.7 |
| OxygenSaturation | 0.961 |
| CarbonDioxideSaturation | 0.0287 |
| EndTidalCarbonDioxideFraction | 0.0479 |
| EndTidalCarbonDioxidePressure(mmHg) | 36.4 |
| TotalAlveolarVentilation(L/min) | 7.21 |
| TranspulmonaryPressure(cmH2O) | 4.92 |
| CoreTemperature(degC) | 37.1 |
| SkinTemperature(degC) | 32.7 |
| RespiratoryExchangeRatio | 0.782 |
| OxygenConsumptionRate(mL/min) | 343 |
| CarbonDioxideProductionRate(mL/min) | 269 |
| GlomerularFiltrationRate(mL/min) | 83.8 |
| RenalBloodFlow(L/min) | 0.758 |
| UrineProductionRate(mL/min) | 0.00 |
| LeftAfferentArterioleResistance(mmHg_min/mL) | 0.0450 |
| RightAfferentArterioleResistance(mmHg_min/mL) | 0.0450 |
| SystemicVascularResistance(mmHg_s/mL) | 1.15 |
| Aorta-Oxygen-PartialPressure(mmHg) | 77.1 |
| Aorta-CarbonDioxide-PartialPressure(mmHg) | 40.3 |
| VenaCava-Oxygen-PartialPressure(mmHg) | 27.1 |
| VenaCava-CarbonDioxide-PartialPressure(mmHg) | 46.3 |
| RightTubules-Sodium-Concentration(g/L) | 4.61 |
| LeftTubules-Sodium-Concentration(g/L) | 4.61 |
| Oxygen-AlveolarTransfer(mL/min) | 309 |
| CarbonDioxide-AlveolarTransfer(mL/min) | -211 |
| MyocardiumVasculature-Oxygen-PartialPressure(mmHg) | 24.6 |
| BrainVasculature-Oxygen-PartialPressure(mmHg) | 24.8 |
| MyocardiumVasculature-InFlow(mL/min) | 166 |
| BrainVasculature-InFlow(mL/min) | 467 |
| VenaCava-InFlow(mL/min) | 3.77e+03 |
| RightHeart-InFlow(mL/min) | 0.00 |
| TotalHemorrhageRate(mL/s) | 4.17 |
| TotalHemorrhagedVolume(mL) | 1.67e+03 |
| BaroreceptorHeartRateScale | 1.65 |
| BaroreceptorHeartElastanceScale | 0.709 |
| BaroreceptorResistanceScale | 1.19 |
| BaroreceptorComplianceScale | 0.905 |
| ChemoreceptorHeartRateScale | 1.17 |
| ChemoreceptorHeartElastanceScale | 1.00 |
Segment 2
Stop the hemorrhages. Run for 120s.
| Property Name | Validation | Engine Value | Percent Error | Percent Change | Notes |
|---|---|---|---|---|---|
| HeartRate(1/min) | LessThan Segment1 (119) [152] | 121 | 1.54% | Increase | |
| MeanArterialPressure(mmHg) | GreaterThan Segment1 (69.1) [152] | 72.8 | 5.34% | Increase | |
| BloodVolume(mL) | EqualTo Segment1 (3.85e+03) | 3.87e+03 | 0.436% | No Change | |
| CardiacOutput(mL/min) | GreaterThan Segment1 (3.44e+03) [152] | 3.76e+03 | 9.14% | Increase | |
| HeartStrokeVolume(mL) | GreaterThan Segment1 (29.0) [152] | 31.2 | 7.48% | Increase | |
| HemoglobinContent(g) | EqualTo Segment1 (572) | 572 | 6.83e-05% | No Change | |
| RespirationRate(1/min) | EqualTo Segment1 (12.7) | 13.3 | 5.19% | No Change |
 |
| Property Name | Engine Value |
|---|---|
| Patient-Weight(kg) | 76.0 |
| HeartRate(1/min) | 119 |
| HeartStrokeVolume(mL) | 29.0 |
| HeartEjectionFraction | 0.312 |
| BloodVolume(L) | 3.85 |
| ExtravascularFluidVolume(L) | 34.1 |
| MeanArterialPressure(mmHg) | 69.1 |
| SystolicArterialPressure(mmHg) | 77.5 |
| DiastolicArterialPressure(mmHg) | 61.2 |
| CardiacOutput(L/min) | 3.44 |
| HemoglobinContent(g) | 572 |
| CentralVenousPressure(mmHg) | 3.13 |
| PulmonaryCapillariesWedgePressure(mmHg) | 3.96 |
| TidalVolume(mL) | 570 |
| RespirationRate(1/min) | 12.7 |
| OxygenSaturation | 0.961 |
| CarbonDioxideSaturation | 0.0287 |
| EndTidalCarbonDioxideFraction | 0.0479 |
| EndTidalCarbonDioxidePressure(mmHg) | 36.4 |
| TotalAlveolarVentilation(L/min) | 7.21 |
| TranspulmonaryPressure(cmH2O) | 4.92 |
| CoreTemperature(degC) | 37.1 |
| SkinTemperature(degC) | 32.7 |
| RespiratoryExchangeRatio | 0.782 |
| OxygenConsumptionRate(mL/min) | 343 |
| CarbonDioxideProductionRate(mL/min) | 269 |
| GlomerularFiltrationRate(mL/min) | 83.8 |
| RenalBloodFlow(L/min) | 0.758 |
| UrineProductionRate(mL/min) | 0.00 |
| LeftAfferentArterioleResistance(mmHg_min/mL) | 0.0450 |
| RightAfferentArterioleResistance(mmHg_min/mL) | 0.0450 |
| SystemicVascularResistance(mmHg_s/mL) | 1.15 |
| Aorta-Oxygen-PartialPressure(mmHg) | 77.1 |
| Aorta-CarbonDioxide-PartialPressure(mmHg) | 40.3 |
| VenaCava-Oxygen-PartialPressure(mmHg) | 27.1 |
| VenaCava-CarbonDioxide-PartialPressure(mmHg) | 46.3 |
| RightTubules-Sodium-Concentration(g/L) | 4.61 |
| LeftTubules-Sodium-Concentration(g/L) | 4.61 |
| Oxygen-AlveolarTransfer(mL/min) | 309 |
| CarbonDioxide-AlveolarTransfer(mL/min) | -211 |
| MyocardiumVasculature-Oxygen-PartialPressure(mmHg) | 24.6 |
| BrainVasculature-Oxygen-PartialPressure(mmHg) | 24.8 |
| MyocardiumVasculature-InFlow(mL/min) | 166 |
| BrainVasculature-InFlow(mL/min) | 467 |
| VenaCava-InFlow(mL/min) | 3.77e+03 |
| RightHeart-InFlow(mL/min) | 0.00 |
| TotalHemorrhageRate(mL/s) | 4.17 |
| TotalHemorrhagedVolume(mL) | 1.67e+03 |
| BaroreceptorHeartRateScale | 1.65 |
| BaroreceptorHeartElastanceScale | 0.709 |
| BaroreceptorResistanceScale | 1.19 |
| BaroreceptorComplianceScale | 0.905 |
| ChemoreceptorHeartRateScale | 1.17 |
| ChemoreceptorHeartElastanceScale | 1.00 |
Segment 2
Provide an IV with packed red blood cells at 5 mL/min with a 2330 mL bag. Run for 2330s.
| Property Name | Validation | Engine Value | Percent Error | Percent Change | Notes |
|---|---|---|---|---|---|
| HeartRate(1/min) | EqualTo Segment2 (121) | 92.4 | 26.5% | No Change | |
| MeanArterialPressure(mmHg) | GreaterThan Segment2 (72.8) [152] | 84.5 | 16.2% | Increase | |
| BloodVolume(mL) | EqualTo Segment2 (3.87e+03) | 4.30e+03 | 10.6% | No Change | |
| CardiacOutput(mL/min) | GreaterThan Segment2 (3.76e+03) [152] | 4.38e+03 | 16.5% | Increase | |
| HeartStrokeVolume(mL) | GreaterThan Segment2 (31.2) [152] | 47.4 | 52.0% | Increase | |
| HemoglobinContent(g) | GreaterThan Segment2 (572) | 615 | 7.45% | Increase | |
| RespirationRate(1/min) | LessThan Segment2 (13.3) [152] | 13.2 | -0.881% | Decrease |
 |
| Property Name | Engine Value |
|---|---|
| Patient-Weight(kg) | 76.0 |
| HeartRate(1/min) | 119 |
| HeartStrokeVolume(mL) | 29.0 |
| HeartEjectionFraction | 0.312 |
| BloodVolume(L) | 3.85 |
| ExtravascularFluidVolume(L) | 34.1 |
| MeanArterialPressure(mmHg) | 69.1 |
| SystolicArterialPressure(mmHg) | 77.5 |
| DiastolicArterialPressure(mmHg) | 61.2 |
| CardiacOutput(L/min) | 3.44 |
| HemoglobinContent(g) | 572 |
| CentralVenousPressure(mmHg) | 3.13 |
| PulmonaryCapillariesWedgePressure(mmHg) | 3.96 |
| TidalVolume(mL) | 570 |
| RespirationRate(1/min) | 12.7 |
| OxygenSaturation | 0.961 |
| CarbonDioxideSaturation | 0.0287 |
| EndTidalCarbonDioxideFraction | 0.0479 |
| EndTidalCarbonDioxidePressure(mmHg) | 36.4 |
| TotalAlveolarVentilation(L/min) | 7.21 |
| TranspulmonaryPressure(cmH2O) | 4.92 |
| CoreTemperature(degC) | 37.1 |
| SkinTemperature(degC) | 32.7 |
| RespiratoryExchangeRatio | 0.782 |
| OxygenConsumptionRate(mL/min) | 343 |
| CarbonDioxideProductionRate(mL/min) | 269 |
| GlomerularFiltrationRate(mL/min) | 83.8 |
| RenalBloodFlow(L/min) | 0.758 |
| UrineProductionRate(mL/min) | 0.00 |
| LeftAfferentArterioleResistance(mmHg_min/mL) | 0.0450 |
| RightAfferentArterioleResistance(mmHg_min/mL) | 0.0450 |
| SystemicVascularResistance(mmHg_s/mL) | 1.15 |
| Aorta-Oxygen-PartialPressure(mmHg) | 77.1 |
| Aorta-CarbonDioxide-PartialPressure(mmHg) | 40.3 |
| VenaCava-Oxygen-PartialPressure(mmHg) | 27.1 |
| VenaCava-CarbonDioxide-PartialPressure(mmHg) | 46.3 |
| RightTubules-Sodium-Concentration(g/L) | 4.61 |
| LeftTubules-Sodium-Concentration(g/L) | 4.61 |
| Oxygen-AlveolarTransfer(mL/min) | 309 |
| CarbonDioxide-AlveolarTransfer(mL/min) | -211 |
| MyocardiumVasculature-Oxygen-PartialPressure(mmHg) | 24.6 |
| BrainVasculature-Oxygen-PartialPressure(mmHg) | 24.8 |
| MyocardiumVasculature-InFlow(mL/min) | 166 |
| BrainVasculature-InFlow(mL/min) | 467 |
| VenaCava-InFlow(mL/min) | 3.77e+03 |
| RightHeart-InFlow(mL/min) | 0.00 |
| TotalHemorrhageRate(mL/s) | 4.17 |
| TotalHemorrhagedVolume(mL) | 1.67e+03 |
| BaroreceptorHeartRateScale | 1.65 |
| BaroreceptorHeartElastanceScale | 0.709 |
| BaroreceptorResistanceScale | 1.19 |
| BaroreceptorComplianceScale | 0.905 |
| ChemoreceptorHeartRateScale | 1.17 |
| ChemoreceptorHeartElastanceScale | 1.00 |
Scenario Output Plots
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