HemorrhageClass4NoFluid

Description

Class 4 hemorrhage.

Segment Validation

Segment 1

Initiate a 75 ml/min hemorrhage from the right arm. Initiate a 125 ml/min hemorrhage from the vena cava. Run for 700s.

Table 1. Data request validation results for Segment 1.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Baseline (72.0) [152]	144		101%	Increase
MeanArterialPressure(mmHg)	EqualTo 57 [152]	31.9	56.4%		~60% Normal
BloodVolume(mL)	EqualTo 3400	3.23e+03	5.19%		Calculated
CardiacOutput(mL/min)	EqualTo 2800 [152]	1.38e+03	67.8%		~50% Normal
HeartStrokeVolume(mL)	LessThan Baseline (80.4) [152]	9.57		-88.1%	Decrease
HemoglobinContent(g)	EqualTo 500	474	5.39%		Calculated
RespirationRate(1/min)	GreaterThan Baseline (12.0) [152]	13.5		12.1%	Increase

Figure 1. Vitals monitor for Segment 1.

Table 2. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	75.3
HeartRate(1/min)	144
HeartStrokeVolume(mL)	9.57
HeartEjectionFraction	0.0897
BloodVolume(L)	3.23
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	31.9
SystolicArterialPressure(mmHg)	34.8
DiastolicArterialPressure(mmHg)	29.4
CardiacOutput(L/min)	1.38
HemoglobinContent(g)	474
CentralVenousPressure(mmHg)	3.61
PulmonaryCapillariesWedgePressure(mmHg)	4.58
TidalVolume(mL)	617
RespirationRate(1/min)	13.5
OxygenSaturation	0.939
CarbonDioxideSaturation	0.0299
EndTidalCarbonDioxideFraction	0.0404
EndTidalCarbonDioxidePressure(mmHg)	30.7
TotalAlveolarVentilation(L/min)	8.31
TranspulmonaryPressure(cmH2O)	8.07
CoreTemperature(degC)	37.2
SkinTemperature(degC)	32.5
RespiratoryExchangeRatio	1.04
OxygenConsumptionRate(mL/min)	252
CarbonDioxideProductionRate(mL/min)	261
GlomerularFiltrationRate(mL/min)	-8.26
RenalBloodFlow(L/min)	0.287
UrineProductionRate(mL/min)	0.00
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0367
RightAfferentArterioleResistance(mmHg_min/mL)	0.0367
SystemicVascularResistance(mmHg_s/mL)	1.23
Aorta-Oxygen-PartialPressure(mmHg)	63.0
Aorta-CarbonDioxide-PartialPressure(mmHg)	37.3
VenaCava-Oxygen-PartialPressure(mmHg)	16.2
VenaCava-CarbonDioxide-PartialPressure(mmHg)	50.8
RightTubules-Sodium-Concentration(g/L)	4.76
LeftTubules-Sodium-Concentration(g/L)	4.76
Oxygen-AlveolarTransfer(mL/min)	202
CarbonDioxide-AlveolarTransfer(mL/min)	-183
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	7.57
BrainVasculature-Oxygen-PartialPressure(mmHg)	12.9
MyocardiumVasculature-InFlow(mL/min)	57.0
BrainVasculature-InFlow(mL/min)	179
VenaCava-InFlow(mL/min)	1.78e+03
RightHeart-InFlow(mL/min)	0.00
TotalHemorrhageRate(mL/s)	3.33
TotalHemorrhagedVolume(mL)	2.33e+03
BaroreceptorHeartRateScale	1.71
BaroreceptorHeartElastanceScale	0.202
BaroreceptorResistanceScale	1.17
BaroreceptorComplianceScale	0.899
ChemoreceptorHeartRateScale	21.6
ChemoreceptorHeartElastanceScale	1.00

Segment 2

Stop the hemorrhages. Run for 15s.

Table 3. Data request validation results for Segment 2.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Segment1 (144) [152]	145		0.128%	Increase
MeanArterialPressure(mmHg)	LessThan Segment1 (31.9) [152]	24.6		-23.0%	Decrease
BloodVolume(mL)	EqualTo Segment1 (3.23e+03)	3.23e+03	0.0355%		No Change
CardiacOutput(mL/min)	LessThan Segment1 (1.38e+03) [152]	851		-38.4%	Decrease
HeartStrokeVolume(mL)	LessThan Segment1 (9.57) [152]	5.89		-38.5%	Decrease
HemoglobinContent(g)	EqualTo Segment1 (474)	474	1.88e-05%		No Change
RespirationRate(1/min)	EqualTo Segment1 (13.5)	13.4	0.447%		No Change

Figure 2. Vitals monitor for Segment 2.

Table 4. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	75.3
HeartRate(1/min)	144
HeartStrokeVolume(mL)	9.57
HeartEjectionFraction	0.0897
BloodVolume(L)	3.23
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	31.9
SystolicArterialPressure(mmHg)	34.8
DiastolicArterialPressure(mmHg)	29.4
CardiacOutput(L/min)	1.38
HemoglobinContent(g)	474
CentralVenousPressure(mmHg)	3.61
PulmonaryCapillariesWedgePressure(mmHg)	4.58
TidalVolume(mL)	617
RespirationRate(1/min)	13.5
OxygenSaturation	0.939
CarbonDioxideSaturation	0.0299
EndTidalCarbonDioxideFraction	0.0404
EndTidalCarbonDioxidePressure(mmHg)	30.7
TotalAlveolarVentilation(L/min)	8.31
TranspulmonaryPressure(cmH2O)	8.07
CoreTemperature(degC)	37.2
SkinTemperature(degC)	32.5
RespiratoryExchangeRatio	1.04
OxygenConsumptionRate(mL/min)	252
CarbonDioxideProductionRate(mL/min)	261
GlomerularFiltrationRate(mL/min)	-8.26
RenalBloodFlow(L/min)	0.287
UrineProductionRate(mL/min)	0.00
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0367
RightAfferentArterioleResistance(mmHg_min/mL)	0.0367
SystemicVascularResistance(mmHg_s/mL)	1.23
Aorta-Oxygen-PartialPressure(mmHg)	63.0
Aorta-CarbonDioxide-PartialPressure(mmHg)	37.3
VenaCava-Oxygen-PartialPressure(mmHg)	16.2
VenaCava-CarbonDioxide-PartialPressure(mmHg)	50.8
RightTubules-Sodium-Concentration(g/L)	4.76
LeftTubules-Sodium-Concentration(g/L)	4.76
Oxygen-AlveolarTransfer(mL/min)	202
CarbonDioxide-AlveolarTransfer(mL/min)	-183
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	7.57
BrainVasculature-Oxygen-PartialPressure(mmHg)	12.9
MyocardiumVasculature-InFlow(mL/min)	57.0
BrainVasculature-InFlow(mL/min)	179
VenaCava-InFlow(mL/min)	1.78e+03
RightHeart-InFlow(mL/min)	0.00
TotalHemorrhageRate(mL/s)	3.33
TotalHemorrhagedVolume(mL)	2.33e+03
BaroreceptorHeartRateScale	1.71
BaroreceptorHeartElastanceScale	0.202
BaroreceptorResistanceScale	1.17
BaroreceptorComplianceScale	0.899
ChemoreceptorHeartRateScale	21.6
ChemoreceptorHeartElastanceScale	1.00

Scenario Output Plots

Figure 3. Select outputs from the scenario.