HemorrhageClass4NoFluid

Description

Class 4 hemorrhage.

Segment Validation

Segment 1

Initiate a 75 ml/min hemorrhage from the right arm. Initiate a 125 ml/min hemorrhage from the vena cava. Run for 700s.

Table 1. Data request validation results for Segment 1.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Baseline (72.0) [152]	145		102%	Increase
MeanArterialPressure(mmHg)	EqualTo 57 [152]	28.5	66.7%		~60% Normal
BloodVolume(mL)	EqualTo 3400	3.23e+03	5.19%		Calculated
CardiacOutput(mL/min)	EqualTo 2800 [152]	1.14e+03	84.2%		~50% Normal
HeartStrokeVolume(mL)	LessThan Baseline (80.4) [152]	7.86		-90.2%	Decrease
HemoglobinContent(g)	EqualTo 500	474	5.39%		Calculated
RespirationRate(1/min)	GreaterThan Baseline (12.0) [152]	13.5		12.6%	Increase

Figure 1. Vitals monitor for Segment 1.

Table 2. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	75.3
HeartRate(1/min)	145
HeartStrokeVolume(mL)	7.86
HeartEjectionFraction	0.0727
BloodVolume(L)	3.23
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	28.5
SystolicArterialPressure(mmHg)	30.9
DiastolicArterialPressure(mmHg)	26.4
CardiacOutput(L/min)	1.14
HemoglobinContent(g)	474
CentralVenousPressure(mmHg)	3.69
PulmonaryCapillariesWedgePressure(mmHg)	4.64
TidalVolume(mL)	619
RespirationRate(1/min)	13.5
OxygenSaturation	0.938
CarbonDioxideSaturation	0.0299
EndTidalCarbonDioxideFraction	0.0396
EndTidalCarbonDioxidePressure(mmHg)	30.1
TotalAlveolarVentilation(L/min)	8.36
TranspulmonaryPressure(cmH2O)	8.13
CoreTemperature(degC)	37.2
SkinTemperature(degC)	32.5
RespiratoryExchangeRatio	1.21
OxygenConsumptionRate(mL/min)	226
CarbonDioxideProductionRate(mL/min)	274
GlomerularFiltrationRate(mL/min)	-14.3
RenalBloodFlow(L/min)	0.248
UrineProductionRate(mL/min)	0.00
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0367
RightAfferentArterioleResistance(mmHg_min/mL)	0.0367
SystemicVascularResistance(mmHg_s/mL)	1.31
Aorta-Oxygen-PartialPressure(mmHg)	62.7
Aorta-CarbonDioxide-PartialPressure(mmHg)	37.3
VenaCava-Oxygen-PartialPressure(mmHg)	16.1
VenaCava-CarbonDioxide-PartialPressure(mmHg)	50.9
RightTubules-Sodium-Concentration(g/L)	4.60
LeftTubules-Sodium-Concentration(g/L)	4.60
Oxygen-AlveolarTransfer(mL/min)	179
CarbonDioxide-AlveolarTransfer(mL/min)	-164
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	6.66
BrainVasculature-Oxygen-PartialPressure(mmHg)	12.0
MyocardiumVasculature-InFlow(mL/min)	49.8
BrainVasculature-InFlow(mL/min)	160
VenaCava-InFlow(mL/min)	1.69e+03
RightHeart-InFlow(mL/min)	3.11e+03
TotalHemorrhageRate(mL/s)	3.33
TotalHemorrhagedVolume(mL)	2.33e+03
BaroreceptorHeartRateScale	1.71
BaroreceptorHeartElastanceScale	0.169
BaroreceptorResistanceScale	1.17
BaroreceptorComplianceScale	0.900
ChemoreceptorHeartRateScale	22.6
ChemoreceptorHeartElastanceScale	1.00

Segment 2

Stop the hemorrhages. Run for 15s.

Table 3. Data request validation results for Segment 2.

Property Name	Validation	Engine Value	Percent Error	Percent Change	Notes
HeartRate(1/min)	GreaterThan Segment1 (145) [152]	146		0.307%	Increase
MeanArterialPressure(mmHg)	LessThan Segment1 (28.5) [152]	19.3		-32.3%	Decrease
BloodVolume(mL)	EqualTo Segment1 (3.23e+03)	3.23e+03	0.0361%		No Change
CardiacOutput(mL/min)	LessThan Segment1 (1.14e+03) [152]	471		-58.7%	Decrease
HeartStrokeVolume(mL)	LessThan Segment1 (7.86) [152]	3.24		-58.8%	Decrease
HemoglobinContent(g)	EqualTo Segment1 (474)	474	3.13e-05%		No Change
RespirationRate(1/min)	EqualTo Segment1 (13.5)	13.4	0.897%		No Change

Figure 2. Vitals monitor for Segment 2.

Table 4. Data requests for Segment 1.

Property Name	Engine Value
Patient-Weight(kg)	75.3
HeartRate(1/min)	145
HeartStrokeVolume(mL)	7.86
HeartEjectionFraction	0.0727
BloodVolume(L)	3.23
ExtravascularFluidVolume(L)	34.1
MeanArterialPressure(mmHg)	28.5
SystolicArterialPressure(mmHg)	30.9
DiastolicArterialPressure(mmHg)	26.4
CardiacOutput(L/min)	1.14
HemoglobinContent(g)	474
CentralVenousPressure(mmHg)	3.69
PulmonaryCapillariesWedgePressure(mmHg)	4.64
TidalVolume(mL)	619
RespirationRate(1/min)	13.5
OxygenSaturation	0.938
CarbonDioxideSaturation	0.0299
EndTidalCarbonDioxideFraction	0.0396
EndTidalCarbonDioxidePressure(mmHg)	30.1
TotalAlveolarVentilation(L/min)	8.36
TranspulmonaryPressure(cmH2O)	8.13
CoreTemperature(degC)	37.2
SkinTemperature(degC)	32.5
RespiratoryExchangeRatio	1.21
OxygenConsumptionRate(mL/min)	226
CarbonDioxideProductionRate(mL/min)	274
GlomerularFiltrationRate(mL/min)	-14.3
RenalBloodFlow(L/min)	0.248
UrineProductionRate(mL/min)	0.00
LeftAfferentArterioleResistance(mmHg_min/mL)	0.0367
RightAfferentArterioleResistance(mmHg_min/mL)	0.0367
SystemicVascularResistance(mmHg_s/mL)	1.31
Aorta-Oxygen-PartialPressure(mmHg)	62.7
Aorta-CarbonDioxide-PartialPressure(mmHg)	37.3
VenaCava-Oxygen-PartialPressure(mmHg)	16.1
VenaCava-CarbonDioxide-PartialPressure(mmHg)	50.9
RightTubules-Sodium-Concentration(g/L)	4.60
LeftTubules-Sodium-Concentration(g/L)	4.60
Oxygen-AlveolarTransfer(mL/min)	179
CarbonDioxide-AlveolarTransfer(mL/min)	-164
MyocardiumVasculature-Oxygen-PartialPressure(mmHg)	6.66
BrainVasculature-Oxygen-PartialPressure(mmHg)	12.0
MyocardiumVasculature-InFlow(mL/min)	49.8
BrainVasculature-InFlow(mL/min)	160
VenaCava-InFlow(mL/min)	1.69e+03
RightHeart-InFlow(mL/min)	3.11e+03
TotalHemorrhageRate(mL/s)	3.33
TotalHemorrhagedVolume(mL)	2.33e+03
BaroreceptorHeartRateScale	1.71
BaroreceptorHeartElastanceScale	0.169
BaroreceptorResistanceScale	1.17
BaroreceptorComplianceScale	0.900
ChemoreceptorHeartRateScale	22.6
ChemoreceptorHeartElastanceScale	1.00

Scenario Output Plots

Figure 3. Select outputs from the scenario.