DrugModel.h

/* Distributed under the Apache License, Version 2.0.
   See accompanying NOTICE file for details.*/
 
#pragma once
 
#include "engine/common/system/Model.h"
#include "engine/common/system/Systems.h"
 
class SEFluidCircuitPath;
class SELiquidCompartment;
class SETissueCompartment;
class SESubstanceCompound;
 
namespace pulse
{
  class PBPhysiology;
  class EngineTest;
  class PULSE_DECL DrugModel : public DrugSystem, public Model
  {
    friend PBPhysiology;//friend the serialization class
    friend EngineTest;
  public:
    DrugModel(Data& data);
    virtual ~DrugModel();
 
    void Clear() override;
 
    // Set members to a stable homeostatic state
    void Initialize() override;
    // Set pointers and other member varialbes common to both homeostatic initialization and loading a state
    void SetUp() override;
 
    void AtSteadyState() override;
    void PreProcess() override;
    void Process(bool solve_and_transport = true) override;
    void PostProcess(bool solve_and_transport = true) override;
 
  protected:
    void ComputeExposedModelParameters() override;
 
    void AdministerSubstanceBolus();
    void AdministerSubstanceInfusion();
    void AdministerSubstanceCompoundInfusion();
 
    void CalculatePartitionCoefficients();
    void CalculateSubstanceClearance();
    void CalculatePlasmaSubstanceConcentration();
    void CalculateDrugEffects();
 
    // Stateless member variable (Set in SetUp)
    SESubstanceCompound* m_Saline;
    SESubstanceCompound* m_Blood;
    SELiquidCompartment* m_aortaVascular;
    SELiquidCompartment* m_venaCavaVascular;
    SELiquidCompartment* m_muscleIntracellular;
    SELiquidCompartment* m_liverVascular;
    SETissueCompartment* m_liverTissue;
    SEFluidCircuitPath* m_IVToVenaCava;
    SETissueCompartment* m_fatTissue;
  };
END_NAMESPACE